疏血通注射液联合阿司匹林治疗糖尿病并急性脑梗死的临床疗效及其对血小板膜糖蛋白Ⅱb和Ⅲa的影响

摘要

Objective To observe the clinical effect of shuxuetong injection combined with aspirin in treating diabetes mellitus patients complicated with acute cerebral infarction,to explore the impact on platelet membrane glycoprotein Ⅱb and Ⅲa.Methods From February 2013 to March 2015,a total of 60 diabetes mellitus patients complicated with acute cerebral infarction were selected in Luwan Branch of Ruijin Hospital Affiliated to Medical College,Shanghai Jiaotong University,and they were divided into control group and test group according random number table,each of 30 cases.Patients of control group received conventional treatment,while patients of test group received shuxuetong injection combined with aspirin based on conventional treatment;both groups continuously treated for 14 days.Clinical effect,blood glucose,platelet membrane glycoprotein Ⅱb and Ⅲa before and after treatment,and incidence of adverse reactions during the treatment were compared between the two groups.Results Clinical effect of test group was statistically significantly better than that of control group(P<0.05).No statistically significant differences of blood glucose,platelet membrane glycoprotein Ⅱb or Ⅲa was found between the two groups before treatment(P>0.05),while blood glucose,platelet membrane glycoprotein Ⅱb and Ⅲa of test group were statistically significantly lower than those of control group after treatment(P<0.05).Incidence of adverse reactions of test group was statistically significantly lower than that of control group during the treatment(P<0.05).Conclusion Shuxuetong injection combined with aspirin has certain clinical effect in treating diabetes mellitus patients complicated with acute cerebral infarction,can effectively reduce the blood glucose,platelet membrane glycoprotein Ⅱb and Ⅲa,with relatively high safety.%目的 观察疏血通注射液联合阿司匹林治疗糖尿病并急性脑梗死的临床疗效,探讨其对血小板膜糖蛋白Ⅱb和Ⅲa的影响.方法 选取2013年2月-2015年3月上海交通大学医学院附属瑞金医院卢湾分院神经内科收治的糖尿病并急性脑梗死患者60例,按照随机数字表法分为对照组和试验组,每组30例.对照组患者给予常规治疗,试验组患者在对照组基础上给予疏血通注射液联合阿司匹林治疗;两组患者均连续治疗14 d.比较两组患者临床疗效,治疗前后血糖、血小板膜糖蛋白Ⅱb和Ⅲa及治疗期间不良反应发生情况.结果 试验组患者临床疗效优于对照组(P<0.05).治疗前两组患者血糖、血小板膜糖蛋白Ⅱb和Ⅲa比较,差异无统计学意义(P>0.05);治疗后试验组患者血糖、血小板膜糖蛋白Ⅱb和Ⅲa低于对照组(P<0.05).试验组患者治疗期间不良反应发生率低于对照组(P<0.05).结论 疏血通注射液联合阿司匹林治疗糖尿病并急性脑梗死的临床疗效确切,可有效降低患者血糖、血小板膜糖蛋白Ⅱb和Ⅲa,且安全性较高.