Objective To analyze the distribution feature of EEG memory processing index in different population groups. Methods From June 2013 to December 2017,a total of 18 164 healthy people were selected as modeling objects from school,enterprise or organization,community,large-scale exhibition,and they were divided into A group(less than 7 years old,n=231),B group(7 to 9 years old,n=544),C group(10 to 13 years old,n=1 159),D group(14 to 24 years old,n=2 179),E group(25 to 39 years old,n=5 609),F group(40 to 65 years old,n=6 472),G group(66 to 80 years old,n=1 522),H group(over 80 years old,n=448)according to the age;research objects were selected as follow:76 elderly dementia patients equal or over≥65 years old as a group,1 237 heart disease diagnosed in a hospital in Beijing as b group,584 pupils in a school in Hebei Province as c group,483 undergraduates in a key university in Beijing as d group,135 coma patients in ICU in a hospital in Beijing as e group,98 children with encephalopathy as f group,94 patients under general anesthesia maintenance phase as g group,91 well-chosen pupils in a attached primary school of a university in Hebei Province as h group,68 hepatic encephalopathy patients in a hospital in Beijing as i group,meanwhile age and gender matched subjects were selected as control-a group(n=76),control-b group(n=1 237),control-c group(n=584),control-d group(n=483), control-e group(n=135),control-f group(n=98),control-g group(n=94),control-h group(n=91),control-i group(n=68) from the modeling objects. HXD-I multi-function combined monitor was used to carry out the EEG examination,then memory processing index was calculated by wavelet method and EEG software package 1.0. Memory processing index was compared in modeling objects with different age,between research objects and corresponding control subjects. Results Memory processing index in A group was statistically significantly lower than that in B group,C group,D group,E group,F group,G group and H group,respectively(P＜0.05);memory processing index in B group was statistically significantly lower than that in C group,D group,E group,F group,G group and H group,respectively(P＜0.05);memory processing index in C group was statistically significantly lower than that in D group,E group,F group,G group and H group,respectively(P＜0.05);memory processing index in D group and E group was statistically significantly higher than that in F group,higher than that in G group and H group,respectively(P＜0.05);memory processing index in F group was statistically significantly higher than that in G group and H group,respectively(P＜0.05);memory processing index in G group was statistically significantly higher than that in H group(P＜0.05). As age grew,memory processing index performed as first increased and decreased afterwards tread,just looked like a inversed "U". Memory processing index in a group,b group,e group,f group and i group was statistically significantly lower than that in control-a group,control-b group,control-e group,control-f group,control-i group,respectively(P＜0.05);memory processing index in c group,d group,g group,h group was statistically significantly higher than that in control-c group,control-d group,control-g group,control-h,respectively(P＜0.05). Conclusion As age grows,memory processing index performs as first increased and decreased afterwards tread,just looks like a inversed "U", which is accord with the law of objective change of memory ability in human life cycle,and memory processing index may occur specific change in different population groups.%目的 分析脑电波记忆加工指数在不同特征人群中的分布特点.方法 2013年6月—2017年12月,从学校、企业或机构、社区、大型展会选取健康人18 164例作为建模对象,根据年龄分为A组(<7岁,n=231)、B组(7～9岁,n=544)、C组(10～13岁,n=1 159)、D组(14～24岁,n=2 179)、E组(25～39岁,n=5 609)、F组(40～65岁,n=6 472)、G组(66～80岁,n=1 522)、H组(>80岁,n=448);选取年龄≥65岁的老年痴呆患者76例(a组)、北京市某医院确诊的心脏病患者1 237例(b组)、河北省某小学学生584例(c组)、北京市某重点大学学生483例(d组)、北京市某医院重症监护病房昏迷患者135例(e组)、脑病患儿98例(f组)、北京市某医院全身麻醉维持期患者94例(g组)、河北省某大学附属小学参与推优的学生91例(h组)、北京市某医院肝性脑病患者68例(i组)作为研究对象,并分别从建模对象中选取年龄、性别相匹配的受试者作为对照a组76例、对照b组1 237例、对照c组584例、对照d组483例、对照e组135例、对照f组98例、对照g组94例、对照h组91例、对照i组68例.采用HXD-I多功能组合式监护仪采集所有受试者脑电波,采用小波算法脑电分析软件包1.0版处理采集到的脑电信号并自动计算记忆加工指数.比较不同年龄段建模对象记忆加工指数,不同研究对象与对照者记忆加工指数.结果 A组记忆加工指数低于B、C、D、E、F、G、H组(P＜0.05);B组记忆加工指数低于C、D、E、F、G、H组(P＜0.05);C组记忆加工指数低于D、E、F组,高于G、H组(P＜0.05);D、E组记忆加工指数高于F、G、H组(P＜0.05);F组记忆加工指数高于G、H组(P＜0.05);G组记忆加工指数高于H组(P＜0.05).随着年龄增长,记忆加工指数呈先升高、后降低的"反U字形"趋势.a、b、e、f、i组记忆加工指数分别低于对照a、b、e、f、i组(P＜0.05);c、d、g、h组记忆加工指数分别高于对照c、d、g、h组(P＜0.05).结论 随着年龄增长,记忆加工指数呈先升高、后降低的"反U字形"趋势,符合人体生命周期中记忆能力的客观变化规律,且不同特征人群记忆加工指数呈特异性变化.
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