ERAS理念对Ⅱ-Ⅲ期结直肠癌围术期患者的临床疗效、免疫应激反应及生活质量的影响分析

摘要

Objective To investigate the ERAS on clinical effect、immunological stress response and living quality of patients with colorectal cancer of Ⅱ ～ Ⅲ stages. Methods To screening 120 cases of patients with colorectal cancer of Ⅱ ～ Ⅲ stages as research subjects, it will be divided into study group with 60 cases and control group with 60 cases, patients in control group were given traditional treatment and patients in study group were given ERAS treatment, then the two groups were compared in terms of clinical efficacy and so on. Results The perioperative period indexes in study group were better than the control group (P ＜ 0.05); The postoperative complication rate in study group was lower than the control group (P ＜ 0.05); One week after operation, the serum Ig A, Ig M, Ig G and C3 levels in study group were higher than the control group (P ＜ 0.05), but the serum CRP level in study group was lower than the control group (P ＜ 0.05); The living quality in study group were significantly better than the control group (P ＜ 0.05). Conclusion The ERAS on patients with colorectal cancer of Ⅱ ～ Ⅲ stages can effectively improve cinical efficacy, reduce stress response and improve the living expectations of the patients, thus it is worthy of cinical promotion.%目的 探讨ERAS理念对Ⅱ～Ⅲ期结直肠癌围术期患者的临床疗效、免疫应激反应及生活质量的影响分析.方法 选取Ⅱ～Ⅲ期结直肠癌患者120例,随机分为两组,对照组60例接受常规围术期治疗,研究组60例接受ERAS理念治疗,比较两组患者围术期相关指标、免疫应激反应及生活质量.结果 术后研究组围术期相关指标优于对照组患者 (P ＜0.05);研究组患者术后总并发症发生率显著低于对照组 (P ＜0.05);术后1周,研究组患者血清免疫球蛋白 (Ig G、Ig A及Ig M) 及补体3 (C3) 水平均高于对照组,而C反应蛋白 (CRP) 水平低于对照组,有统计学差异 (P ＜0.05);术后2周,研究组患者的生活质量各评分及总评分均明显高于对照组 (P ＜0.05).结论 快速康复治疗在Ⅱ～Ⅲ期结直肠癌围术期患者的治疗中安全有效,可加快其术后康复,显著减少其应激反应的发生,同时可有效提高其生活质量,值得临床大力推广.