Objective To analyze the clinical pathological features of multiple colorectal cancer and impact of surgery on postoperative quality of life ( QOL) .Methods Clinical pathological characteristics in 596 colorectal cancer patients who received surgical treatment were retrospectively analyzed .There were 35 multiple colorectal cancer ( multiple cancer group ,5.9%) and 561 single colorectal cancer(single cancer group,94.1%).The clinical pathological characteristics were analyzed between the 2 groups,and gastrointestinal quality of life index (GIQLI) was used to assess the impact of surgery on postoperative QOL .Results There were 81 niduses in 35 cases,and 12 adenomatoid polyps with the canceration rate of 33.3%.Multiple cancer group had bigger proportion of adenoma canceration ,the position of nidus in single cancer group was usually in rectum .After surgery for 1 month,the QOL was remarkably reduced ,and the GIQLI score in 6 months was significantly higher than that before surgery and 1 month after surgery (P<0.05),The self-conscious symptom returned to preoperative levels .Conclusion Multiple colorectal cancer is easily associated with polyposis and canceration ,and is most frequently happened in rectum .Surgery is helpful to im-prove patients ’ QOL,and postoperative follow-up and monitoring should be strengthened .%目的：分析多原结直肠癌的临床病理特征及手术治疗对术后生活质量的影响。方法回顾性分析596例结直肠癌患者临床病理资料，其中单发结直肠癌（单发癌组）561例（94．1％），多原结直肠癌（多原癌组）35例（5．9％），比较两组患者临床及病理特点，采用胃肠生活质量量表（ GIQLI）评价手术治疗对患者生活质量的影响。结果35例患者共有病灶81个，并发腺瘤样息肉12枚，癌变率33．3％。多原癌组中腺瘤癌变比例较大，单发癌组以直肠部位居多。术后1个月患者的生活质量较术前明显降低，术后6个月GIQLI的总分明显高于术前和术后1个月的（P＜0．05），自觉症状恢复至术前水平。结论多原结直肠癌易伴发息肉病恶变，且以直肠部位居多，手术有助于改善患者的生活质量，术后应加强随访和监测。
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