奈达铂与顺铂分别联合同期放疗治疗中晚期宫颈癌的临床疗效比较

摘要

目的：比较奈达铂与顺铂联合同期放疗治疗中晚期宫颈癌的临床疗效。方法按照随机数字表法将86例中晚期宫颈癌患者均分为实验组和对照组，实验组患者采用奈达铂联合同期放疗治疗，对照组患者采用顺铂联合同期放疗治疗。比较2组患者近期疗效、不良反应发生情况以及随访12个月复发转移和无转移生存情况。结果2组患者临床疗效比较，差异无统计学意义（ P＞0．05）；2组患者随访12个月复发转移率和无转移生存率比较，差异均无统计学意义（P＞0．05）。实验组患者恶心呕吐发生率显著低于对照组，差异具有统计学意义（P＜0．05）；2组患者贫血、血细胞下降、血小板下降、腹泻发生率比较，差异无统计学意义（P＞0．05）。结论奈达铂与顺铂联合同期放疗治疗中晚期宫颈癌疗效相近，但采用奈达铂治疗的恶心呕吐发生率更低，可作为化疗优选药物。%Objective To explore the clinical efficacy of nedaplatin or cisplatin chemotherapy and concurrent radiothera-py for middle and advanced cervical cancer.Methods 86 cases of advanced cervical carcinoma were randomly divided into the experiment group and the control group.The control group were treated by cisplatin combined with concurrent chemoradiotherapy, the experiment group were treated by nedaplatin combined with concurrent chemoradiotherapy.The clinical efficacy,side effects, relapse and metastasis in 12 months were compared between the 2 groups.Results There had no significant difference in the clinical efficacy between the 2 groups(P>0.05);There had no significant difference in the rate of relapse and metastasis between the 2 groups(P>0.05);The rate of nausea and vomiting in the experiment group were lower than that of the control group(P<0.05);There had no significant difference in the rate of anemia,pancytopenia,thrombocytopenia,and diarrhea between the 2 groups(P>0.05).Conclusion Nedaplatin or cisplatin and concurrent radiotherapy for middle and advanced cervical cancer have similar clinical efficacy,but nedaplatin combined with concurrent chemoradiotherapy has low rate of nausea and vomiting.It can be used as optimal chemotherapy drugs.