组织学病理学和分子分类对乳腺癌的病理诊断价值

摘要

Objective To investigate the value of histological and molecular classification in the pathologic diagnosis of breast cancer .Methods Tissue sections of 745 cases of breast cancer received immunohistochemistry examination , and were classified by histological ,pathological and molecular classification ,and the characteristics were compared .Results 745 patients were divided into 5 molecular subtypes:235 cases of luminal A ,95 cases of luminal B type ,141 cases of over-expression of the ep-idermal growth factor receptor type ,142 cases of triple negative type ,and 132 cases unclassified.Conclusion The histological classification and molecular classification are related .Histological classification combined with molecular classification can help guide diagnosis and treatment of breast cancer .%目的：探讨组织学分类和分子分类在乳腺癌病理诊断中的价值。方法对745例乳腺癌患者组织切片进行免疫组织化学检验，分别进行组织学分类、病理学分类和分子分类，比较各自的分类特点。结果745例分为5种分子亚型：235例管腔A型，95例管腔B型，141例表皮生长因子受体过表达型，142例三阴性型，132例未分类。结论乳腺癌组织学分类与分子分类相关。联合组织学分类和分子分类，有助于指导乳腺癌的诊断和治疗。