手术去势间断联合多西他赛治疗晚期前列腺癌的疗效观察

摘要

目的：探讨手术去势间断联合多西他赛治疗晚期前列腺癌的临床疗效。方法收集75例转移性前列腺癌患者的病历资料。按照临床治疗方法不同将患者分为实验组和对照组，实验组28例，对照组47例。实验组患者采取睾丸切除去势＋多西他赛治疗，对照组患者采取睾丸切除去势治疗。观察患者的临床疗效、PSA水平、疼痛评分及不良反应发生情况，观察患者生活质量评分变化情况。结果实验组患者治疗后PSA水平、疼痛评分低于治疗前和对照组，差异有统计学意义（P＜0．05）；治疗后，对照组患者PSA水平、疼痛评分低于治疗前，差异有统计学意义（P＜0．05）。实验组患者红细胞、白细胞减少，恶心呕吐，骨髓抑制，手足综合征，脱发发生率显著低于对照组，差异有统计学意义（P＜0．05）。实验组患者生活质量评分高于治疗前和对照组，差异有统计学意义（P＜0．05）；治疗后，对照组患者生活质量评分高于治疗前，差异有统计学意义（ P＜0．05）。实验组患者中位生存时间、无进展生存时间、2年生存率均高于对照组，差异有统计学意义（P＜0．05）。结论手术去势间断联合多西他赛治疗晚期前列腺癌效果较好，能改善患者PSA水平、疼痛情况，减少不良反应发生情况，提高患者的生活质量，临床应用价值较高。%Objective To explore the clinical efficacy of surgical castration intermittent combined with docetaxel treat -ment for advanced prostate cancer .Methods 75 cases of patients with metastatic prostate cancer were divided into the experi-ment group and the control group .The control group were treated by testicular resection castration +docetaxel,the control group were treated by testicular resection castration .The clinical effects ,the levels of PSA ,the scores of pain ,complication ,the scores of quality of life were compared .Results The levels of PSA ,the scores of pain for the experiment group were lower than prior treat-ment and the control group(P<0.05);The levels of PSA,the scores of pain of the control group were lower than prior treatment (P<0.05);The rate of red cell,hypoleucocytosis,nausea and vomit,myelosuppression,hand-foot syndrome,alopecia of the ex-periment group were lower than the control group (P<0.05);The scores of quality of life of the experiment group were higher than prior treatment and the control group ( P<0.05);The scores of quality of life of the control group were higher than prior treatment(P<0.05);The median survival time,progression-free survival,2-year survival of the experiment group were higher than the control group(P<0.05).Conclusion It has good clinical effects for patients with metastatic prostate cancer by testicu-lar resection castration+docetaxel,it can improve the levels of PSA,pain,reduce the complication,increase the quality of life,it has high clinical application value .