目的 对比分析核素153Sm与89SrCl2对广泛转移性骨肿瘤患者的治疗效果.方法 选择广泛转移性骨肿瘤患者85例,随机分为153Sm组与89SrCl2组,分别采用核素153Sm以及89SrCl2进行治疗.比较2组的生活质量、骨痛缓解效果以及临床疗效.结果 89SrCl2组的生活质量改善有效率为73.80％(31/42),明显高于153Sm组的58.14％(25/43)(P<0.05);89SrCl2组的骨痛缓解有效率为92.86％(39/42),明显高于153Sm组的74.42％(32/43)(P<0.05);89SrCl2组的治疗有效率为83.33％(35/42),明显高于153Sm组的60.46％(26/43)(P<0.05).结论 核素89SrCl2对广泛转移性骨肿瘤患者的治疗效果明显优于153Sm,可以有效改善患者的生活质量,明显缓解骨痛情况.%Objective To compare the therapeutic effects of 153Sm and 89SrCl2 for patients with extensive metastatic bone tumors.Methods 85 patients with extensive metastatic bone tumors were selected and randomly divided into 2 groups:153Sm and 89SrCl2.Respectively,patients with extensive metastatic bone tumors were treated using 153Sm(43 patients)and 89SrCl2(42 patients).The quality of life,the effect of pain relief and clinical curative for 153Sm(43 patients)and 89SrCl2(42 patients)were compared.Results In 89SrCl2 group,the efficiency of life improvement was 73.80％(31/42).And the efficiency of life improvement was 58.14％(25/43)in 153Sm group.The efficiency of life improvement in 89SrCl2 group was higher than 153Sm group(P<0.05).The efficiency of pain relief was 92.86％(39/42)in 89SrCl2 group.The efficiency of pain relief in 153Sm group was 74.42％(32/43),which was less than 89SrCl2 group(P<0.05).The efficiency of treatment was 83.33％in 89SrCl2 group(35/42),which was significantly higher than that 60.46％in 153Sm group(26/43)(P<0.05).Conclusion The therapeutic effect of radionuclide 89SrCl2 for extensive metastatic bone tumors is better than153Sm.While 89SrCl2 group can relief bone pain and improve patient's life quality.
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