经阴道彩色多普勒超声病灶内微血管与早期宫颈癌预后发展的关系

摘要

目的 探讨经阴道彩色多普勒超声病灶内微血管情况与早期宫颈癌的预后情况的关系,给予早期宫颈癌的诊疗及预后评估提供参考依据.方法 收集80例宫颈浸润癌患者的完整临床资料,采用统计学方法分析经阴道彩色多普勒超声早期宫颈癌病灶内血管生成、血流参数情况与其经手术治疗后的临床预后指标及病理特征的相关性.结果 宫颈癌病灶内微血管血流丰富与临床Ⅱ期、间质浸润≥10.0 mm、脉管受累、肿瘤直径≥15.0 mm、宫旁浸润≥10.0 mm、淋巴结转移相关(P<0.05);PI及RI与间质浸润深度、有无转移存在相关性(P<0.05),不同血流情况组术前超声早期宫颈癌病灶微血管情况(PI、RI、血流情况)比较差异有统计学意义(P<0.05),丰富血流组的PI、RI明显低于血流不丰富及血流不明显组(P<0.05).不同预后风险组术前超声早期宫颈癌病灶微血管情况(PI、RI、血流情况)比较差异有统计学意义(P<0.05),高风险组的PI、RI明显低于中、低风险组,血流也比低风险组更加丰富(P<0.05).结论 经阴道彩色多普勒超声病灶内微血管情况与早期宫颈癌的预后发展存在相关性,宫颈癌灶内血流情况及血流动力学参数可用于预测早期宫颈癌的预后.%Objective To study the relationship between the transvaginal color doppler flow imaging ( TV-CDFI) of in-tralesional capillaries and prognosis of early cervical cancer ,and offer reference for early cervical cancer diagnosis and prognosis assessment.Methods Collected the complete clinical information of 80 cases of patients with cervical invasive carcinoma .Ex-plored the relevance between the TV-CDFI intralesional angiogenesis ,blood flow parameters and its clinical prognostic indicators and pathologic characteristics after surgery in the early cervical cancer .Results The intralesional microvascular rich blood flow was correlated with clinical stageⅡ,depth of stromal invasion greater equal 10.0mm,vascular involvement ,tumor infiltration grea-ter equal 10 mm,depth of parametrical extension greater equal 15.0 mm and cancer metastasis(P<0.05).The PI and RI were correlated with stromal infiltration depth and presence of shift correlation (P<0.05),The comparative difference of preoperative ultrasound early cervical lesion condition ( PI,RI and blood flow) between different microvascular blood flow group was statistically significant(P<0.05),and the PI and RI of abundant blood flow group were obviously lower than the groups that blood flow was not rich and obvious(P<0.05).The comparative difference of early stage cervical cancer lesions microvascular preoperative ul -trasonography situation(PI,RI and blood flow)between different prognostic risk group was statistically significant (P<0.05),PI and RI of high-risk group was obviously lower than low risk group ,and blood flow was more abundant than low risk group ( P<0.05).Conclusion The TV-CFDI of intralesional capillaries is correlated with the prognosis of early cervical cancer ,and the blood flow and hemodynamic parameters within thecervix lesions can be used to predict the prognosis of early cervical cancer .