GP化疗联合同步放疗治疗老年非小细胞肺癌的疗效及对免疫功能、生活质量的影响

摘要

目的 探讨GP化疗联合同步放疗治疗老年非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及对免疫功能、生活质量的影响. 方法 选择90例老年NSCLC病人,随机分为对照组和试验组,每组45例.对照组病人给予单纯GP化疗方案,试验组病人给予GP化疗联合同步放疗,2组病人均治疗2个疗程.评价并比较2组病人临床疗效,检测并比较2组病人治疗前后血清中CD3+、CD4+、CD8+及自然杀伤(NK)细胞所占的比值.采用体力状况评分(Karnofsky performance status, KPS)表来评估2组病人治疗后生活质量的改善情况. 结果 治疗后,试验组病人的缓解率(response rate, RR)和疾病控制率(disease control rate, DCR)均明显高于对照组,差异具有统计学意义(P<0.05).治疗前,2组病人外周血中CD3+、CD4+、CD8+及NK细胞所占的比值比较,差异无统计学意义(P>0.05);治疗后,试验组病人外周血中CD3+、CD4+、CD8+及NK细胞所占的比值较治疗前明显升高,且均明显高于对照组,差异均具有统计学意义(P<0.05).治疗后,试验组病人KPS评分提高率为86.67%,明显高于对照组病人的64.44%,差异具有统计学意义(P<0.05). 结论 GP化疗联合同步放疗治疗老年NSCLC临床疗效显著,能够明显改善病人细胞免疫功能,提高病人的生活质量,值得在临床上推广应用.%Objective To study the clinical efficacy of GP chemotherapy combined with concurrent radiotherapy in the treatment of non-small cell lung cancer and effects on immune function and quality in the elderly patients.Methods A total of 90 elderly patients with non-small cell lung cancer(NSCLC) were enrolled, and were divided into control group (n=45) and treatment group (n=45) randomly.The control group was treated with GP chemotherapy, while the treatment group was treated with GP chemotherapy combined with concurrent radiotherapy.The two groups were treated for 2 weeks.The clinical efficacy of two groups were compared.The ratio of peripheral blood CD3+, CD4+, CD8+and NK cells of two groups before and after treatment were detected and compared.The quality of life (QOL) of two groups after treatment were assessed by Karnofsky performance status.Results After treatment, the response rate and disease control rate of treatment group were significantly higher than those of control group (P<0.05).There were no significant differences in ratio of the peripheral blood CD3+, CD4+, CD8+and NK cells between the two groups before treatment (P>0.05).The ratio of peripheral blood CD3+, CD4+, CD8+and NK cells of the treatment group after treatment were significantly higher than those before treatment (P<0.05),and than those of control group after treatment (P<0.05).The improvement rate of the KPS scores of the treatment group was 86.67%, which was significantly higher than that of the control group (64.44%, P<0.05).Conclusions GP chemotherapy combined with concurrent radiotherapy in the treatment of elderly patients with NSCLC has good clinical efficacy, and it can significantly improve the immune function and QOL.