乙酰辅酶A羧化酶抑制剂的构效关系和抗性研究进展

摘要

乙酰辅酶A羧化酶(ACCase)抑制剂是以乙酰辅酶A羧化酶为作用靶标的一类除草剂.这类除草剂通过抑制真核型乙酰辅酶A生成丙二酰辅酶A的羧化反应,进而抑制植物脂肪酸的合成,多用于苗后有选择性地防除一年生禾本科杂草.本文综述了该类除草剂的作用机理、构效关系及在应用中的抗性研究进展.%Acetyl-CoA carboxylase is one of the targets of ACCase inhibitor herbicides. A carboxylation reaction from an eukaryotic type of acetyl coenzyme A to malonyl coenzyme A can be inhibited by such herbicides, and then, fatty acid biosynthesis could be inhibited. It is used for a selective herbicide to control the annual postemer-gence weeds. The mechanism of action, construction and weed resistance were briefly summarized in this paper.