42例利妥昔单抗药品不良反应/事件报告分析

摘要

采用回顾性研究方法,对42例利妥昔单抗药品不良反应/事件(ADR/ADE)报告进行综合分析:有20例是急性输注反应,其中发生过敏性休克3例;血液系统、皮肤及附件损害各6例；肝损害5例；胃肠道损害3例,含1例出现胃肠穿孔；肾功能异常、高血压加重各1例.利妥昔单抗可引起严重ADR/ADE,须加强该药ADR/ADE的研究及防治.%A total of 42 adverse drug reactions/event (ADR/ADE) reports induced by rituximab in Jiangsu province were analyzed in order to investigate the epidemiological characteristics of ADR/ADE induced by rituximab. Among the ADR/ADE, 20 cases were acute infusion reactions, included three allergic shock cases; six cases in each were blood system lesions and the skin and appendages lesions; five cases were liver damages; three cases were gastrointestinal lesions, included one gastrointestinal perforation; one for each were renal dysfunction and increased hypertension. It should be strengthened the observation and evaluation of rituximab ADR/ADE.