地氯雷他定对过敏性哮喘豚鼠模型肺组织IL-4R mRNA表达的影响

摘要

Objective: To study the effects of desloratadine on the expression of IL-4 receptor mRNA in lung tissues of allergic asthma guinea pig. Methods: The allergic asthma model of guinea pig was induced by ovalbumin. Then the effects of desloratadine were observed on the pathological changes and the expression of IL-4 receptor mRNA in lung tissues. ResuIts: Desloratadine could improve the pathological changes and decrease the expression of IL-4 receptor mRNA in lung tissues. ConcIusion: Decreasing the expression of IL-4 receptor mRNA in lung tissues may be the mechanism of desloratadine in treating asthma.%目的：研究地氯雷他定对过敏性哮喘豚鼠模型肺组织IL-4R mRNA表达的影响。方法：用卵蛋白制备过敏性哮喘豚鼠模型，观察地氯雷他定对过敏性哮喘豚鼠肺组织病理及IL-4R mRNA表达水平的影响。结果：地氯雷他定能显著改善过敏性哮喘豚鼠肺组织病理变化，明显降低肺组织IL-4R mRNA表达水平。结论：降低肺组织IL-4R mRNA的表达可能是地氯雷他定防治哮喘的基因机制。