1例SLCO1B1*5等位基因携带者服用辛伐他汀致横纹肌溶解症的案例分析

摘要

Objective: To explore the characteristics and risk factors of statin related myopathy. Methods: One case of rhabdomyolysis induced by taking simvastatin was analyzed retrospectively and the SLCO1B1 genotype of this patient was detected. Results: Age, gender, renal insufficiency, combination and SLCO1B1*5 allele could be the main causes of rhabdomyolysis. Conclusion: Patients should be given statins by individualized medication. Myopathy high-risk patients should take low doses and be closely monitored. Genetic testing can screen risks for patients.%目的：探求他汀类相关肌病发生特点及易感因素。方法：报告1例服用辛伐他汀导致横纹肌溶解症，并对患者进行SLCO1B1基因型检测。结果：高龄、性别、肾功能不全、联合用药及携带SLCO1B1*5等位基因可能为该患者发生横纹肌溶解症的主要原因。结论：他汀类药物应采取个体化用药，肌病高危患者宜采取低剂量，并严密监测，通过基因检测可对患者进行风险筛查。