Objective To evaluate the efficacy and safety of the percutaneous vertebroplasty (PVP) for osteoporotic thoracolumbar vertebral compression fractures, and to summary measures to avoid complications of the surgery. Methods A retrospective analysis of the patients with steoporotic thoracolumbar vertebral com-pression fractures treated by PVP from Mar. 2010 to Jan. 2014 was done, with a total number of 45 patients and 60 vertebral lesions. The outcomes were assessed by visual analogue score ( VAS) and Oswestry disability index ( ODI) before and after the operation. T-test was done using the SAS software. Results Forty-five pa-tients with osteoporotic compression fractures were treated with PVP. After the treatment, the VAS scores were decreased by 5. 87±1. 00 (at the 3rd day) and 4. 25±1. 28 (in 1 year), meanwhile the ODI scores decreased by 54. 97±4. 92 (at the 3rd day) and 41. 47±5. 88 (in 1 year). There was no statistically significant difference between thoracic vertebra fractures and lumbar vertebra fractures after the surgery. Bone cement leakage oc-curred in 5 patients after the surgery, but there was no nerve dysfunction or pulmonary embolism. Conclusion PVP is a safe and effective measure for osteoporotic thoracolumbar compression fractures. PVP has the same efficacy to thoracic vertebra fractures and lumbar vertebra fractures caused by osteoporosis. The new PVP mate-rials need further study to support their safety. At present, strict indications, a grasp of injecting bone cement quantity and speed, and standard operation are effective methods to prevent complications.%目的:评价经皮椎体成形术(percutaneous vertebroplasty,PVP)治疗骨质疏松型胸腰椎压缩性骨折的效果及安全性,探讨避免手术并发症的措施。方法回顾性分析2010年3月至2014年1月我院采用经椎弓根入路双侧PVP治疗骨质疏松型胸腰椎压缩性骨折的患者45例,按病变部位分为胸椎组,腰椎组和合并胸腰椎骨折组,分别于术后3 d、术后1年随访患者,以视觉模拟评分法( visual analogue score,VAS)和Oswestry功能障碍指数( Oswestry disability index,ODI)为评价指标,应用SAS软件进行t检验分析,比较治疗前后VAS和ODI评分的差异。结果45例骨质疏松型压缩性骨折患者行PVP治疗后3 d、1年VAS评分分别降低了(5.87±1.00)分、(4.25±1.28)分,ODI评分分别下降了(54.97±4.92)分、(41.47±5.88)分,术后3 d、1年胸椎组、腰椎组VAS评分和ODI评分,差异均无统计学意义(均P>0.05)。 PVP治疗过程中5例患者发生骨水泥渗漏,但无神经损坏、肺栓塞等并发症。结论PVP是治疗骨质疏松型胸腰椎压缩性骨折的一种安全、有效的治疗方式。 PVP对骨质疏松引起的胸椎、腰椎骨折疗效相当。 PVP新型材料的安全性还需进一步研究探讨。严格掌握适应证、规范的操作、把握好推注骨水泥量和速度是目前预防并发症的有效方法。
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