重组人骨形态发生蛋白-2结合纳米晶胶原基骨材料植骨融合在腰椎不稳症中的临床应用

摘要

目的 观察重组人骨形态发生蛋白-2 (rhBMP-2)结合纳米晶胶原基骨材料(nHAC)行腰椎间融合治疗腰椎不稳症的疗效.方法 2008年1月～2010年12月23例(27个节段)腰椎不稳患者,所有患者均行腰椎椎弓根螺钉固定系统,辅助以rhBMP-2结合nHAC椎间植入融合椎体.结果 全部病例获随访,手术后平均随访13.5月,按照JOA评价标准,优14例,良6例,可3例.优良率86.9%.结论 rhBMP-2结合nHAC行腰椎间融合治疗腰椎不稳症是一种比较理想的治疗方法.%Objective To investigate the clinic effect of the recombinant human bone morphogenetic protein-2 ( rhBMP-2 ) mix with nano-hydroxyapatite collagen (nHAC ) to treat lumbar segmental instability. Method From Jan 2008 to Dec 2010, 23 patients ( 27 segments ) with umbar segmental instability were treated by internal fixation of Lumbar Spon-dylolisthesis assist with rhBMP-2 and nHAC. Result All cases were followed 13.5 months, judge by JO A, excellent Meases, good 6 cases, the good-excellent were 86.9%. Conclusion rhBMP-2 mix with nHAC to treat lumbar segmental instability is a ideal therapy method.