平阳霉素瘤内注射对婴幼儿血管瘤血清中血管内皮生长因子表达的影响

摘要

Objective:To explore clinical effect of intratumoral injection of pingyangmycin (PYM) on expression of vascular endo-thelial growth factor (VEGF) in infantile hemangioma serum in proliferative stage and its significance.Methods:23 infantile hemangi-oma cases in proliferative stage were enrolled to measure the content of VEGF in hemangioma serum by enzyme -linked immunosorbent assay (ELISA) before and 3 days,7 days,14 days after intralesional injection of PYM.Results:The expression of VEGF in hemangio-ma serum 3 days and 7 days after intralesional injection of PYM decreased significantly as compared to that before treatment (P<0.05), while there was no statistical difference between expression of VEGF in hemangioma serum 14 days after intralesional injection of PYM and that before injection (P>0.05).Conclusions:Intratumoral injection of pingyangmycin to treat infantile hemangioma in proliferative stage can obviously decrease expression of VEGF in hemangioma serum , but it has timeliness.It remains open to question to evaluate the growth rate of infantile hemangioma and clinical effectiveness of PYM for infantile hemangioma based on only the expres -sion of VEGF in hemangioma serum.%目的：探讨平阳霉素瘤内注射对婴幼儿增殖期血管瘤血清中血管内皮生长因子（vascular endothelial growth factor ， VEGF）表达的影响及意义。方法：选取增殖期血管瘤婴幼儿23例，分别于平阳霉素瘤内注射治疗前及治疗后3、7、14 d时采集瘤内血，应用酶联免疫吸附（ELISA）法检测瘤内血清中VEGF的含量。结果：平阳霉素瘤内注射治疗后3 d和7 d时，瘤内血清中VEGF表达水平较治疗前明显降低（P＜0.05）；治疗后14 d时，瘤内血清中VEGF表达水平与治疗前相比，其差异无统计学意义（P＞0.05）。结论：平阳霉素瘤内注射治疗婴幼儿增殖期血管瘤，能明显降低瘤内血清中VEGF表达水平，但具有时效性，仅依此来评估婴幼儿血管瘤生长增殖速度及平阳霉素的治疗效果有待商榷。