Objective To investigate the prognostic factors of malignant melanoma (MM), supporting the diagnosis and treatment for the disease. Method 227 cases of MM which had complete data of medical record and follow up were retrospectively analyzed. Then we selected 13 variables which might be potential factors influencing the prognosis, in-cluding:gender, age, ulceration, satellite lesions, pathological type, lymph node metastasis at onset of disease, the number of metastatic lymph nodes, pathological stage, tumor thickness, intervention history, range of surgical resection, radiother-apy and combined therapy history. Life table method was adopted to obtain the survival time and survival rate, Kaplan-Meier and Log-Rank test were applied for univariate analysis, and then Cox regression analysis was performed for those factors with statistical significance. Results As of May 2012, a total of 110 cases of death were observed, and the 1-, 3-, 5-, and 7-year OS rates were 81.4%, 60.3%, 46%, and 37.9%, respectively, with a median survival time (MST) of 57 months. Univariate analysis showed that, there were eight factors, such as ulceration, pathological type, tumor thickness, lymph node metastasis at onset of disease, the number of metastatic lymph nodes, pathological stage, range of surgical re-section and combined treatment could influence the prognosis of patients, with statistical significance observed (P<0.05). Multivariate Cox regression analysis showed that tumor thickness, pathological stage, combined therapy and range of sur-gical resection were independent prognostic factors of MM patients (P<0.05), in which the tumor thickness, pathological stage were risk factors, while combined therapy and range of surgical resection were protective factors. Conclusion The tumor thickness, pathological stage, range of surgical resection and combined therapy were independent prognostic fac-tors that could affect the survival of MM patients.%目的：分析恶性黑色素瘤（MM）患者的预后影响因素，为进一步提高我国MM诊治水平提供参考。方法回顾性分析227例病历、随访资料完整的MM患者，选择性别、年龄、溃疡、卫星病灶、病理类型、发病时有无淋巴结转移、转移淋巴结数量、病理分期、肿瘤厚度、干涉史、手术切除范围、放疗史和综合治疗13个可能对患者预后产生影响的因素，采用寿命表法进行生存时间和生存率分析。Kaplan-Meier法Log-rank检验进行单因素分析，对单因素有统计学意义的再进行Cox回归模型多因素分析。结果截至2012年5月共死亡110例，其1、3、5、7年总生存率（OS）分别是81.4%、60.3%、46%、37.9%，中位生存期（MST）为57个月。单因素分析显示：溃疡、病理类型、肿瘤厚度、发病时有无淋巴结转移、转移淋巴结数量、病理分期、手术切除范围和综合治疗8个因素对MM患者的预后影响有统计学意义（P﹤0.05）。Cox回归模型多因素分析显示：肿瘤厚度、病理分期、综合治疗和手术切除范围是影响MM患者长期生存的独立预后因素（P﹤0.05），其中肿瘤厚度、病理分期是危险因素，综合治疗、手术切除范围是保护因素。结论肿瘤厚度、病理分期、手术切除范围和综合治疗是影响MM患者生存的独立预后因素。
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