ILT4与Ki67在上皮性卵巢癌淋巴结转移患者中的表达情况

摘要

目的：探讨免疫球蛋白样转录子4（ILT4）与Ki67在上皮性卵巢癌淋巴结转移患者中的表达情况。方法回顾性分析70例上皮性卵巢癌患者，通过淋巴结转移情况分为淋巴结转移组（37例）和无淋巴结转移组（33例），观察两组患者ILT4、Ki67的表达情况。结果免疫组织化学结果显示，淋巴结转移组中，卵巢癌组织中ILT4表达水平低于无淋巴结转移组，Ki67表达水平高于无淋巴结转移组（P﹤0.05）；淋巴结转移组ILT4阳性率35.14%（13/37）低于无淋巴结转移组的84.85%（28/33），差异有统计学意义（P﹤0.05）；淋巴结转移组Ki67阳性率表达81.08%（30/37）高于无淋巴结转移组的45.45%（15/33），差异有统计学意义（P﹤0.05）。结论在上皮性卵巢癌淋巴结转移患者中，ILT4水平表达降低，Ki67表达升高，可将其作为诊断病情的指标。%Objective To investigate the expression profile of ILT4 and Ki67 in patients with epithelial ovarian carci-noma and lymph node metastasis. Method A retrospective analysis was performed in 70 patients with epithelial ovarian cancer, who were stratified as lymph node metastasis group (n=37) and non-lymph node metastasis group (n=33) by re-spective status of metastasis. The expression of ILT4 and Ki67 in both groups were analyzed. Result In immunohisto-chemical analysis, the expression of ILT4 in ovarian cancer tissue of metastasis group was lower than that in non-metasta-sis group, while the expression of Ki67 was higher in the former than that in the latter (P<0.05);the positive rate of ILT4 expression in metastasis group was 35.14%(13/37), lower than that in non-metastasis group at 84.85%(28/33), with sig-nificant difference observed (P<0.05); while the positive rate of Ki67 was 81.08% (30/37) in metastasis group, higher than that in non-metastasis group at 45.45%(15/33), which was of significant difference (P<0.05). Conclusion In epitheli-al ovarian cancer patients with lymph node metastasis, it is common that low ILT4 expression is accompanied by high ex-pression of Ki67, which can be used as an important index for the diagnosis.