自体外周血造血干细胞移植治疗外周T细胞淋巴瘤的临床研究

摘要

目的 探讨自体外周血造血干细胞移植对外周T细胞淋巴瘤的治疗效果的影响.方法 选取收治的191例非霍奇金淋巴瘤患者,其中外周T细胞淋巴瘤67例,符合入组条件的60例纳入研究.依据随机数字表法将患者分为治疗组及对照组各30例,治疗组患者给予常规化疗联合自体外周血造血干细胞移植后大剂量放化疗进行治疗,对照组患者给予常规化疗方案进行治疗.统计比较两组患者的血象恢复时间、疗效、生活质量情况、不良反应、生存情况.结果 治疗组患者中性粒细胞恢复≥1.5×109/L及血小板恢复≥20×109/L的时间分别为(11.63±2.86)d和(15.24±2.49)d;治疗组患者治疗过程中出现发热例数多于对照组患者,差异有统计学意义(P﹤0.05);治疗组患者生存时间和无进展生存时间均长于对照组患者,差异有统计学意义(P﹤0.05);治疗组患者的生活质量优于对照组患者,差异有统计学意义(P﹤0.05).结论 自体外周血造血干细胞移植有效提高外周T细胞淋巴瘤疗效的同时还对患者的生活质量有改善作用,延长患者生存时间和无进展生存时间,移植后有部分患者出现发热,经对症处理可缓解.%Objective To explore the effect of autologous peripheral blood stem cell transplantation for patients with peripheral T-cell lymphoma. Method 191 cases of non-Hodgkin's lymphoma were treated in our hospital, in which there were 67 cases of peripheral T-cell lymphoma, among which 60 patients were included, and were randomized as study group and control group according to a random number table,with 30 cases in each.The patients in the study group were given high-dose radiochemotherapy after conventional chemotherapy and autologous peripheral blood stem cell transplantation;while patients in the control group were administered with routine chemotherapy regimen.The hemato-poietic reconstitution time,therapeutic effect,quality of life score,survival and adverse reactions were compared between the two groups.Result In the study group,the median time to neutrophil recovery as≥1.5×109/L and platelet recovery as≥20×109/L were(11.63±2.86)d and(15.24±2.49)d,respectively;the number of fever cases in the study group was sig-nificantly more than that in the control group (P0.05); the survival time and progression-free survival time in study group were better than those in the control group(P0.05);the quality of life of the patients in study group was signifi-cantly higher than that in the control group(P0.05).Conclusion Autologous peripheral blood hematopoietic stem cell transplantation can improve the curative effect and the quality of life of patients,prolong the survival time and progres-sion-free survival, while fever may appear in some patients after transplantation, and can be relieved by symptomatic treatment.