Objective To investigate the characteristics of the expression of fork transcription factor (FoxM1) pro-tein, and to analyze the correlation with pathological features and prognosis of cervical cancer. Method A total of 90 specimens of cervical cancer tissues collected after surgery (cervical cancer group) and 45 cases of normal cervical tissues (control group) were included in the analysis, immunohistochemical staining was used to detect the expression of FoxM1 protein in the two groups, and to analyze the correlation between FoxM1 protein and clinical manifestations and out-comes of 5 years of follow-up. Result The positive expression of FoxM1 protein in cervical cancer tissues was 74.44％, which was significantly higher than that of control group at 8.89％(P<0.01);positive expression of FoxM1 protein in cer-vical cancer tissues was associated with FIGO stage, tumor differentiation, and myometrial invasion (P<0.05);the surviv-al time of patients with positive FoxM1 protein expression was longer than those with negative expression (P<0.05). Con-clusion FoxM1 protein is highly expressed in cervical cancer tissues, which is closely related to the occurrence, develop-ment and poor prognosis of cervical cancer.%目的 探讨叉头转录因子(FoxM1)蛋白在宫颈癌组织中的表达特点,并分析其与宫颈癌病理学特征及患者预后的关系.方法 选取手术后宫颈癌组织标本90例(宫颈癌组)及正常宫颈组织45例(对照组),采用免疫组化染色法检测两组标本中FoxM1蛋白的表达情况,并分析FoxM1蛋白与宫颈癌患者临床特征、5年随访结局的关系.结果 宫颈癌组织中的FoxM1蛋白阳性表达率为74.44％,明显高于对照组的8.89％(P﹤0.01);宫颈癌组织中的FoxM1蛋白阳性表达与患者的FIGO分期、肿瘤分化程度、发生肌层浸润有关(P﹤0.05);FoxM1蛋白阳性表达的宫颈癌患者的生存时间短于阴性表达患者(P﹤0.05).结论 FoxM1蛋白在宫颈癌组织中高表达,与宫颈癌的发生发展及不良预后关系密切.
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