目的：探讨亚低温联合大剂量巴比妥类药物治疗重型颅脑损伤患者的临床效果。方法：选择2015年1月～2016年3月收治的重型颅脑损伤患者136例，随机分为对照组42例、试验组50例和联合组44例，对照组实施常规治疗，试验组实施亚低温治疗，联合组实施亚低温联合巴比妥治疗，对比三组治疗后1，3，7 d颅内压（ICP）水平及预后情况。结果：和联合组在治疗1，3，7 d后ICP均较对照组降低；联合组在治疗1，3 d后ICP较试验组低，但治疗7 d后两组ICP无明显差异。伤后6个月格拉斯哥预后评分结果示试验组和联合组预后的良好例数高于对照组；联合组的植物状态率低于对照组和试验组；对照组的病死率高于试验组和联合组。结论：亚低温联合大剂量巴比妥类药物治疗重型颅脑损伤能够降低颅内压，改善临床预后。%Objective:To explore the clinical effect of mild hypothermia treatment combined with large dose of barbiturates in the treatment of patients with severe craniocerebral injury.Methods:Selected 136 patients with severe craniocerebral injury admitted in our hospital from January 2015 to March 2016 and randomly divided them into control group (n=42),experimental group (n=50) and combined group (n=44).The control group was treated with conven-tional therapy.The experimental group was treated with mild hypothermia treatment .The combined group was treated with mild hypothermia treatment com-bined with barbiturate treatment.The intracranial pressure (ICP) levels and prognosis of the three groups at 1st, 3rd and 7th day after the treatment were compared.Results: The ICP in the combined group at 1st, 3rd and 7th day after the treatment were lower than that in the control group.The ICP of the combined group at 1st and 3rd day after the treatment were lower than that of the experimental group , but there was no significant difference between the two groups 7 days after the treatment.The 6-month Glasgow prognosis score showed that the numbers of favorable cases in the experimental group and the com-bined group were higher than that in the control group.The rate of plant condition in the combined group was lower than that in the control group and the experimental group.The mortality rate in the control group was higher than that in the experimental group and the combined group .Conclusion:Mild hypo-thermia treatment combined with high dose of barbiturates treatment can decrease the intracranial pressure and improve the prognosis of patients with severe craniocerebral injury.
展开▼
