In order to explore this type of 99mTc-GH and N2S2 ligands exchange reaction as a common method for the preparation of 99mTc-N2S2 complexes, detailed kinetic study of ligand exchange reaction between 99mTc-GH and ECD was carried out. This paper presents preliminary results from the study at different ligand concentrations and pH values. The ligand exchange reaction is a second order reaction. Its rate constant being pH dependent were determined as: kpH2=1.11×104 l.mol-1. min-1, kpH5=1.34×104 l.mol-1 min-1, kpH6=2.24×104 l. mol-1.min-1.
展开▼