Objective:To study the executive function of schizophrenia patients in completing different diffi-culty level of Tower of London (TOL), and to confirm the suitability of TOL as a cognitive assessment tool for schizophrenia patients. Methods:Twenty-seven schizophrenia patients (patients group) and 28 healthy volun-teer (control group) were given computerized TOL assessment. The response time and correct rate would be collected and analyzed. Results:On medium difficulty questions, patients and control groups didn’t have a dif-ference in time required for solving TOL items. However, time required on solving problems were significantly higher in easy and difficult questions (P<0.05), and the accuracy was significantly lower than the control group in all difficulties (P<0.01). In addition, a within group comparison showed significant lengthening of time and lowering of accuracy when comparing between easy and difficult levels (P<0.001). Moreover, the problem solving time of TOL was positively correlated to cognitive symptoms in easy level (r=0.499, P<0.05), while in higher difficulties, problem solving time was negatively correlated to excitability-Hostility symptoms (r=-0.452, P<0.05;r=-0.553, P<0.05);also, the correct response rate is negatively correlated to cognitive symp-toms in higher difficulties (r=-0.438, P<0.01;r=-0.672, P<0.01). Conclusion:TOL may be a suitable tool for cognitive ability assessment, while the cognitive function may be affected by impulse and cognitive related symptoms.% 目的：研究精神分裂症患者在完成不同难度等级的伦敦塔（TOL）任务中的执行功能，并确认TOL作为精神分裂症认知功能测量工具的适当性。方法：精神分裂症患者27例（患者组），健康对照者28例（对照组），分别进行电子化TOL测试，记录分析2组解题时间和答题正确率。结果：患者组在中等难度等级的测验中，答题时间与对照组无差异，但在其他难度等级的任务中，答题时间均明显高于对照组（P<0.05）；在所有等级的任务难度中，患者组的答题正确率显著低于对照组（P<0.01），且患者组在低难度等级的任务中的答题时间低于难度等级较高的任务（P<0.001），答题正确率下降(P<0.001)；另外，TOL的解题时间与认知症状呈显著正相关（r=0.499，P<0.05），在中、高难度中则与兴奋症状呈负相关（r=-0.452， P<0.05；r=-0.553，P<0.05）；答题正确率在中、高难度与认知症状呈显著负相关（r=-0.438，P<0.01；r=-0.672，P<0.01)。结论：TOL宜作为精神分裂症认知功能测量工具，而精神分裂症患者的认知功能可能在TOL测验中的反应时间与正确率上受到冲动与认知相关症状的影响而出现异常。
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