不同时间点启动他汀类药物治疗对缺血性卒中患者预后的影响

摘要

目的:探讨不同时机启动他汀类药物治疗对急性缺血性卒中患者预后的影响.方法:急性缺血性卒中患者94例,根据启动他汀类药物的时间点分为A组50例(发病24 h内启动)和B组44例(发病后24～72h启动).收集2组的基线资料并随访出院后3月的美国国立卫生研究院卒中量表(NIHSS)评分、改良RanKin量表(mRS)评分及卒中复发、预后不良及死亡、不良反应等发生情况.结果:随访3月后,A组的mRS评分、NIHSS评分优于B组,差异有统计学意义(P＜0.05);A组终点事件发生率(预后不良、卒中复发)低于B组,差异有统计学意义(P＜0.05),2组的死亡率、不良反应发生率差异无统计学意义(P＞0.05).结论:卒中后的24 h内早期启动他汀类药物有益于改善缺血性卒中患者的预后.%Objective:To explore the effect statins treatment at different time points on the prognosis of patients with acute ischemic strokes.Methods:Ninety-four patients with acute ischemic strokes were enrolled and assigned to two groups according to the starting time of using statins,i.e.,50 patients in the early-use group in which patients who took Statins within 24 hours after stroke(group A) and 44 patients in the late-use group in which patients who took Statins in 24～72 hours after stroke(group B).The data of mRS score,NIHHS score recurrent incidence and poor prognosis after 3 months were collected.Results:The mRS score and NIHHS score after 3 month in group A were better than that in group B (P＜0.05).The rate of poor prognosis and recurrent stroke in the group A were lower than those in the group B (P＜0.05).There was no significant differences in mortality and adverse reaction rate between the two groups (P＞0.05).Conclusion:Early use of Statins within 24 hours after stroke onset could improve the prognosis of patients with acute ischemic strokes.