中药新药筛选新技术及实践

摘要

This article focused on summarization of the available new screening technology for traditional Chinese medicine (TCM) new drug, including high throughput screening (HTS), biological chip, molecular biological chro-matography, high content screening (HCS), network pharmacology, proteomics, and computer-aided drug design (CADD). And in this review, one example that we applied CADD technology (such as molecular docking, pharma-cophore and molecular similarity) in lipid-lowering TCM new drug development was given. Based on the mechanism of lipid metabolism, CADD technology provided a good method on the prescription optimization and mechanism study. In addition, TCM new drug development proposal which displayed in this paper may provide a useful strategy for screening of TCM new drug.%本文扼要概述了当前可运用于中药新药筛选的高通量筛选、生物芯片、分子生物色谱、高内涵筛选、网络药理学、蛋白质组学和计算机辅助虚拟筛选等新技术和新方法，并结合本单位研究开发实践，基于调脂代谢机理，将计算机辅助虚拟筛选技术，如分子对接、药效团、分子相似度等应用到中药新药的筛选、处方优化和作用机理研究中，为中药新药筛选研发工作提供借鉴。