This study was aimed to discuss the effect mechanism of Gui-Lu Er-Xian (GLEX) glue intervention in Alzheimer's disease (AD) from the regulation of cerebral blood circulation and then explore the scientific connotation of tonifying kidney and marrow. A total of 60 patients, who were diagnosed as AD in modern medicine and kidney-marrow deficiency syndrome in traditional Chinese medicine (TCM), were randomly divided into two groups, with 30 patients in each group. Cases in the control group were treated with Donepezil Hydrochloride Tablets. And cases in the treatment group were treated with GLEX. The treatment course was 60 days. Transcranial doppler (TCD) parameters were monitored before and after treatment in both groups. The results showed that compared with pretreatment, Vp, Vd in MCA, ACA, PCA, VA and BA were obviously increased in both groups after treatment (P<0.05 or P< 0.01), and PI, RI were obviously decreased (P< 0.05 or P< 0.01). Compared with the control group, Vp, Vd in MCA, ACA, PCA, VA and BA in the treatment group were obviously higher than the control group after treatment (P< 0.05 or P< 0.01), and PI, RI were obviously decreased (P< 0.05 or P< 0.01). It was concluded that GLEX glue can improve cerebral blood circulation among AD patients. This may be one of the mechanisms of enriching marrow by tonifying kidney.%目的：从调节脑部血液循环角度探讨龟鹿二仙胶干预阿尔茨海默病（AD）的效应机制，进而探索补肾生髓的科学内涵。方法：60例西医诊断为阿尔茨海默病，中医诊断为肾虚髓空证的患者随机分成两组，每组30例。对照组采用安理申干预治疗，治疗组采用龟鹿二仙胶治疗，疗程为60天，两组治疗前后分别监测经颅多普勒超声（TCD）相关参数。结果：与治疗前比较，两组治疗后患者大脑中动脉（MCA）、前动脉（ACA）、后动脉（PCA）、椎动脉（VA）及基底动脉（BA）5脑部血管的收缩期峰值血流速度（Vp）、舒张末期血流速度（Vd）皆明显升高（P<0.05或P<0.01），搏动指数（PI）及阻力指数（RI）皆明显下降（P<0.05或P<0.01）；与对照组比较，治疗后治疗组患者MCA、ACA、PCA、VA及BA 5脑部血管的Vp、Vd皆明显升高（P<0.05或P<0.01），PI、RI皆明显降低（P<0.05或P<0.01）。结论：龟鹿二仙胶具有改善AD患者脑部血液循环的作用，此可能为其补肾生髓的机制之一。
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