基于神经血管单元稳态探索开心解郁方抗抑郁作用机制

摘要

神经血管单元(NVU)是以神经元、小胶质细胞、血脑屏障以及维持脑组织完整性的细胞外基质等多种成员组成的动态功能模块,NVU的主要成员是神经系统疾病发生发展的结构基础之一,参与了抑郁症的病理过程.抑郁症神经血管单元失稳态主要以神经血管解耦联、血脑屏障通透性增高及神经炎症反应等为特征.中药治疗抑郁症具有辨证论治、整体调节等优势,开心解郁方治疗抑郁症疗效显著,本文旨在从脑白质功能连通性、保护神经元及胶质细胞损伤、保护血管内皮细胞,修复血脑屏障以及减轻神经炎症等角度阐述开心解郁方对NVU的影响,为中医药治疗抑郁症提供新的理论依据和思路方法.%The neurovascular unit (NVU) is a dynamic functional module composed of neurons,microglia,blood-brain barrier (BBB) and the extracellular matrix that maintains the integrity of brain tissues.The chief members of NVU are one of the structural bases of the development of nervous system diseases.And they are involved in the pathological process of depression.The NVU instability of depression is characterized by the uncoupling of nerve and blood vessels,the increase of BBB permeability and the inflammatory response.Traditional Chinese medicine (TCM) has many advantages in the treatment of depression,and the effect of Kai-Xin Jie-Yu (KXJY) decoction in treating depression is remarkable.The purpose of this study was to explain the effect of KXJY decoction on NVU in terms of the functional connectivity of brain white matter,the protection of neurons and glial cells,the protection of vascular endothelial cells,the repair of BBB and the reduction of inflammation.It provided a new theoretical basis and method for the treatment of depression in TCM.