目的：比较MTX+孕囊穿刺和单独药物治疗剖宫产术后子宫瘢痕妊娠患者的临床疗效。方法回顾性分析2013年1月~2014年7月我院收治的137例CSP患者资料，按治疗方法分为两组，A组（n=68）采用单独药物治疗，B组（n=69）采用MTX+孕囊穿刺治疗。结果 A组治愈率与B组比较差异有统计学意义（P＜0.05）。B组治疗后1周、治疗后2周血β-HCG水平与A组比较明显降低，血β-HCG水平恢复至正常所需时间短于A组，出血量少于A组，平均住院天数及转经时间均短于A组（P＜0.05）。A组及B组术后FSH、LH、E2水平比较差异无统计学意义（P＞0.05）。结论 MTX+孕囊穿刺治疗剖宫产术后子宫瘢痕妊娠的临床疗效与单独药物治疗的疗效比较有显著优势，能缩短血β-HCG水平恢复正常的时间、减少出血量、缩短住院时间及月经恢复时间，可以在临床推广应用。%Objective To compare the clinical efficacy of MTX+ pregnant bursa puncture,single drug therapy for the treatment of cesarean scar pregnancy patients. Methods Retrospectivly analyzed the information of 137 CSP patients in our hospital from Jan 2013 to Jul 2014 and divided into two groups, group A (n=68) used single drug therapy, group B (n=69) used MTX+ pregnant bursa puncture therapy. Results The cure rate in group A compared with group B showed significant difference (P<0.05). Group B after one week treatment and two weeks treatment, serum β-HCG level was significantly lower than group A, the time that bloodβ-HCG levels recoverd back to normal was shorter than group A, the amount of bleeding was less than group A, the average of hospital stays and turning time were shorter than group A (P<0.05). FSH, no pre-LH, E2 level of two groups had no statistically significant difference (P>0.05). Conclusion The clinical efficacy cesarean scar preg-nancy treated with MTX + pregnant bursa puncture therapy has significant advantage than single drug therapy , can shorten the time that blood β-HCG level recovers back to normal, reduce the amount of bleeding, shorter hospital stays and recovery time of menstruation, it can be applied in clinic.
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