自体DC-CIK细胞回输联合化疗治疗晚期恶性实体瘤疗效观察

摘要

Objective To explore the curative effect in the near future that autologous DC-CIK cells transfusion com-bined with chemotherapy in the treatment of advanced malignant solid tumor. Methods Observed the curative effect that au-tologous DC-CIK cells transfusion combined with chemotherapy in the treatment of advanced malignant solid tumor , and the pe-ripheral blood cytokins, tumor markers, gastrointestinal reactions, bone marrow suppression,the quality of life,kamofsky grade. Results There was 0 case completely response (CR) in twenty advanced tumor patients that cured by chemotherapy, part re-sponse(PR) of 1 case,minimal remission (MR) of 2 cases,stable disease(SD) of 7 cases, progressive disease(PD) of 10 cases. The remission rate was 15%,disease control rate was 50%. There was 1 case of CR in united group, PR of 2 cases, MR of 4 cases,SD of 10 cases, PD of 3 cases. The remission rate was 35%,disease control rate was 85%. There were statistical signifi-cant differences between the two groups. For the cancerous pain,spirit condition,sleep,fatigue and weakness of qualitative index live marked improvement and bone marrow suppression. There were statistical significant differenece between the two groups. There were no statistical significant difference between the two groups on the tumor markers and peripheral bood cytokins. Conclusion The curative effect that autologous DC-CIK cells transfusion combined with chemotherapy in the treatment of ad-vanced malignant solid tumor is better than that cured by chemotherapy. It improves the life quality of advanced tumor patients and kamofsky grade,reduces bone marrow suppression,doesn't increase gastrointestinal reactions, tumor makers and blood cy-tokins don't change.%目的：观察化疗联合自体DC-CIK细胞回输治疗晚期恶性实体瘤的近期疗效。方法观察单纯化疗(对照组)和化疗联合自体DC-CIK细胞回输（联合组）治疗晚期恶性实体肿瘤疗效，主要观察指标：治疗前后外周血细胞因子、肿瘤标志物、胃肠道反应及骨髓抑制、生活质量、KPS评分。结果对照组20例治疗后CR 0例，PR 1例，MR 2例，SD 7例；PD 10例，缓解率为15%，DCR为50%。联合组治疗后CR 1例，PR 2例，MR 4例，SD 10例，PD 3例，缓解率35%，DCR为85%。两组DCR比较差异有统计学意义（χ2=5.58，P＜0.05）。生存质量指标癌性疼痛、精神、睡眠、疲乏无力联合组比对照组改善明显，两组比较差异都有统计学意义（P＜0.05）；联合组和对照组胃肠道反应比较差异无统计学意义（χ2=1.71，P＜0.05）；联合组和对照组骨髓抑制情况比较差异有统计学意义（χ2=4.91，P＜0.05）；联合组治疗前后肿瘤标志物及外周血细胞因子计数变化比较无统计学差异（P＞0.05）。结论自体DC-CIK细胞回输联合化疗治疗晚期恶性实体瘤DCR比单纯化疗者高，并且能够改善晚期肿瘤患者生存质量、KPS评分，减轻化疗后骨髓抑制情况，但胃肠道反应无明显差异。肿瘤标志物及细胞因子无明显变化。