扬州地区结核与非结核分枝杆菌耐药现状分析

摘要

Objective To summarize situation of mycobacterium tuberculosis and nontuberculosis mycobacteria drug re-sistance, to provide the reference basis for the drug choice of tuberculosis chemotherapy. Methods Differential medium (PNB) and thiophene p-nitrobenzoic acid - 2 - hydroxy acid hydrazine (TCH) were done early screening to identify bacteria mycobacterium type,absolute concentration method of detection of drug resistance. Results Tuberculosis separation rate of mycobacterium was 94.63% (141/149),the separation rate of nontuberculosis mycobacteria was 5.37% (8/149),group of mul-tidrug-resistant mycobacterium tuberculosis rate was 14.18%,49.65% of the total resistance. Of multidrug-resistant nontubercu-losis mycobacteria rate was 87.5%, the total resistance rate was 100%. Resistance of mycobacterium tuberculosis in TH1321 , SM,INH and RFP,nontuberculosis mycobacteria was similar to mycobacterium tuberculosis group of high drug resistance. Conclusion Tuberculosis in Yangzhou mainly is mycobacterium tuberculosis,the region of multi-drug resistant rate and total resistance is higher than the national level,the separation rate of nontuberculosis mycobacteria is low,but should be very alert.%目的：通过总结近年来扬州地区结核与非结核分枝杆菌耐药现状，为该地区肺结核病化疗选择药物提供参考依据。方法通过鉴别培养基对硝基苯甲酸（PNB）和噻吩-2-羟酸肼（TCH）做分枝杆菌菌型初筛鉴别，绝对浓度法检测耐药。结果结核分枝杆菌群分离率为94.63%（141/149），非结核分枝杆菌分离率为5.37%（8/149）；结核分枝杆菌群耐多药率14.18%，总耐药率49.65%。非结核分枝杆菌耐多药率87.5%，总耐药率100%。结核分枝杆菌群以耐TH1321、SM、INH和RFP多见，非结核分枝杆菌高耐药与结核分枝杆菌群相似。结论本地区肺结核以结核分枝杆菌群为主，耐多药率及总耐药率高于全国水平，非结核分枝杆菌分离率较低，但临床应十分警惕。