乳结散治疗中老年乳腺增生疗效及其对患者血清中雌孕激素受体表达的影响

摘要

目的：探讨乳结散治疗中老年乳腺增生的疗效及其对患者血清中雌孕激素受体表达的影响。方法于2012年5月~2014年5月选择我院88例入院治疗乳腺增生的中老年患者作为研究对象。以数字法随机分为观察组与对照组，各44例。对观察组患者施以乳结散治疗，对照组施以枸橼酸他莫昔芬片治疗。对比观察两组治疗疗效及乳结散对血清中雌孕激素受体表达的影响。结果两组经过治疗后，观察组的证候积分明显少于对照组，而生活质量评分明显高于对照组。观察组疗效为优者占比73.86%（65/88），优良率为97.73%（86/88），均显著高于对照组的59.09%（52/88），86.36%（76/88），P均<0.05，差异具有统计学意义。两组经过治疗后，观察组的ER以及PR的阳性率均明显低于对照组，P均<0.05，差异具有统计学意义。结论乳结散对于中老年乳腺增生的治疗具有较为明显的效果，会减小其对于雌孕激素的敏感性，安全性较高，值得临床推广使用。%Objective To investigate the efficacy of Rujiesan in middle-aged and elderly patients with hyperplasia of mammary glands and its influence on the expression of serum estrogen receptor (ER) and progesterone receptor (PR). Meth-ods 88 middle-aged and elderly patients with hyperplasia of mammary glands in our hospital from May 2012 to May 2014 were selected as the subjects. The patients were divided into the observation group and control group by random number method , 44 patients in each group. Patients in the observation group were given Rujiesan , while patients in the control group were given ta-moxifen citrate tablets. Efficacy of treatment and the influence on the expression of serum ER and PR were compared between two groups. Results After treatment, the symptom score of the observation group was significantly lower than that of the con-trol group, while the life quality score of the observation group was significantly higher than that of the control group. The excel-lent efficacy rate in the observation group was 73.86% (65/88), and the excellent and good efficacy rate was 97.73% (86/88), which were both significantly higher than 59.09% (52/88) and 86.36%(76/88) in the control group, and the difference was statis-tically significant (P<0.05). After treatment, the ER and PR positive rates in the observation group were both lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Rujiesan has obvious effect on the hyperplasia of mammary glands in middle-aged and elderly patients, which can reduce the sensitivity of patients to estrogen and progesterone. With high safety, it is worthy of wide clinical application.