肾交感神经消融对快速起搏心衰犬左室收缩功能的保护作用研究

摘要

Objective To investigate whether renal sympathetic nerve ablation can protect the systolic function of left ventricular (LV) during the progression of heart failure (HF). Methods 19 beagle dogs were randomly divided into three groups:sham-operated group (n=6), control group (n=7) and ablation group (n=6). Sham-operated group were implanted with pacemakers without pacing. Control group were implanted with pacemakers and underwent 3 weeks of rapid right ventricular pacing, and ablation group bilateral renal sympathetic nerve ablation first, at the same time implanted with pacemakers. 3 days after the rapid right ventricular pacing. Left ventricular strain were analyzed by two-dimensional speckle traching imaging Re-sults After 3 weeks, all the dogs in the control group and ablation group showed greater LV end-diastolic volume compared with the sham-operated group, however, the dogs in the ablation group had a higher LV ejection fraction (LVEF) than the con-trol group (P<0.05). The LV systolic strains were higher in the ablation group than in the control group (P<0.05) for longitudi-nal, circumferential and radial strain, respectively. Conclusion Renal sympathetic nerve ablation can protect the systolic function of left ventricular during the progression of heart failure in dogs.%目的：观察肾交感神经消融是否可以保护心衰犬左室收缩功能。方法19只比格犬随机分为3组：假手术组（n=6）、对照组（n=7）和消融组（n=6）。假手术组犬装起搏器，但不开启；对照组装好起搏器后开始快速右室起搏3周；消融组先对双侧肾交感神经消融，同时植入起搏器，3d后开启快速右室起搏。左室应变通过超声二维斑点追踪技术来评价。结果3周后，对照组和消融组犬左室舒张末期容积较假手术组大；但是，消融组犬左室射血分数高于对照组（P<0.05）。长径方向、圆周方向和径向方向上左室收缩期应变消融组均高于对照组（P<0.05）。结论肾交感神经消融可以保护心衰犬左室收缩功能。