养心汤联合倍他乐克对扩张型心肌病心衰患者的疗效及对神经内分泌因子的影响

摘要

目的:探讨扩张型心肌病(DCM)心衰应用养心汤联合倍他乐克治疗的临床效果.方法:选取我院收治的168例DCM心衰患者,采取随机数字表法等分为两组.对照组(84例)给予倍他乐克治疗,观察组(84例)在此基础上加用养心汤治疗.比较两组临床疗效和治疗前后神经内分泌因子[肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、内皮素(ET)、醛固酮(ALD)、血栓素B2(TXB2)]水平变化.结果:治疗3个月后,观察组总有效率为86.90％(73/84),明显高于对照组[73.81％(62/84),P＜0.01].两组治疗后各神经内分泌因子(PRA、AngⅡ、ET、ALD、TXB2)血浆浓度均显著低于治疗前(P＜0.01),且观察组下降更显著(P＜0.01).结论:DCM心衰应用养心汤联合倍他乐克治疗能明显减轻患者症状,调控神经内分泌水平,疗效确切,值得临床推广.%Objective:To explore clinical effect of Yangxin Decoction combined with betaloc on dilated cardiomyopathy (DCM) with heart failure.Methods:Selected 168 cases with DCM with heart failure in our hospital as research objectives, and divided them into two groups randomly. Provided betaloc to control group, and provided Yangxin Decoction combined with betaloc to observation group. Compared two groups' clinical effect, neuroendocrine [renin (PRA), angiotensin Ⅱ (AngⅡ), endothelin (ET), aldosterone (ALD), thromboxane B2 (TXB2) ] before and after treatment.Results:After 3 months treatment, observation group's overall effect rate was 86.09％ (73/84) which was significant higher than control group's [73.81％ (62/84), P＜0.01]. Two groups' plasma concentrations of each neuroendocrine [renin (PRA), angiotensin Ⅱ (AngⅡ), endothelin (ET), aldosterone (ALD), thromboxane B2 (TXB2) ] after treatment were significant lower than those before treatment (P＜0.01), and observation group's decreased more significantly (P＜0.01).Conclusion:Yangxin Decoction combined with betaloc helps patients with DCM with heart failure to reduce symptoms, regulate neuroendocrine levels with exact effect, and it is worthy of clinical promotion.