Objective It is to approach the anti inflammatory action of Edaravone in treatment of acute cerebral infarction through observing the level changes of serum high sensitivity C reactive protein in patients wich acute cerebral infarction before and after the use of Edaravone. Methods 100 patients wich acute cerebral infarction were randomly divided into treatment group ( n = 50 ) and control group ( n = 50 ). The control group was treated with Danshen injection and cytidine diphosphate choline by intravenous drip once a day. The treatment group was treated with Edaravone 30 mg intravenous drip once a day based on the treatment of the control group. The level changes of serum high sensitivity C reactive protein before and after treatment for 3 d, 7 d and 14 d were detected with radio-immunity turbidity method. The neurologic impairment scores were noted down. Results Serum high sensitivity C reactive protein reached the highest level at the 3rd day and then decreased slowly. The levels of serum high sensitivity C reactive protein in the treatment group at the 7th day after treatment were obviously lower than that in the control group and the difference was significant ( P＜0.05 ). The neurologic impairment scores in the treatment group at the 14th day after treatment were obviously lower than that in the control group and the difference was more significant ( P＜0.01 ). Conclusion Edaravone can lower the levels of serum high sensitivity C reactive protein in the treatment on acute cerebral infarction, which is made for relieving the inflammatory reaction and improving ischemia, hypoxia and defective neural function.%目的 通过观察急性脑梗死患者使用依达拉奉前后血清高敏C反应蛋白水平的变化,探讨依达拉奉在急性脑梗死治疗中的抗炎作用.方法 选择100例急性脑梗死患者,将其随机分为治疗组和对照组各50例,对照组每天静脉应用丹参注射液、胞二磷胆碱等药物,治疗组给予依达拉奉30 mg静滴每日1次,其他用药同对照组.应用放射免疫比浊法检测治疗前,治疗后3 d、7 d、14 d的血清高敏C反应蛋白水平变化,并进行神经功能缺损标准评分.结果 2组患者在脑梗死后3 d高敏C反应蛋白水平最高,随后渐降低,治疗后7 d治疗组高敏C反应蛋白水平明显低于对照组,有显著性差异(P<0.05).治疗后14 d治疗组神经功能缺损评分明显低于对照组,有极显著性差异(P<0.01).结论 依达拉奉治疗急性脑梗死患者可以降低其血清高敏C反应蛋白水平,有利于减轻炎症反应,改善脑梗死缺血缺氧和缺损的神经功能.
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