Objective It is to evaluate the effect of local anaesthesia on pain in different period after tonsillectomy.Meth-ods The PubMed, EMbase, the Cochrane Library (Issue 11, 2014), CNK, WanFang Data, and VIP were searched to select randomized controlled studies ( RCTs) about the study on the curative effect of local anaesthesia on pain in different time after tonsillectomy pain published as the language of Chinese and English from inception to November 2014.According to the inclu-sion and exclusion criteria, performing to literature filtrate and data extraction, it was used RevMen 5.2 software to obtain me-ta-analysis results.Results This study included sixteen literatures.The results of Meta-analysis showed that, the score of post-operation pain in test group was lower than that in control group[SMD=-0.63, 95%CI( -1.00, -0.25), P=0.0009;I2 =86%], the topical anaesthetic group [SMD=-0.61, 95%CI(-1.02, -0.20), P=0.004;I2 =83%] and the minor group[SMD=-1.19, 95%CI( -1.54, -0.84), P<0.00001;I2 =67%〗by subgroup were statistical signifi-cance in major outcome of between 4 to 6 hours after the surgery;the overall group[SMD=-0.72, 95%CI( -1.27, -0. 16), P=0.01;I2 =88%] and the minor group[SMD=-1.01, 95%CI( -1.49, -0.54), P<0.0001;I2 =80%] by subgroup were statistical significance in secondary outcome of 3 hours after the surgery; the overall group[ SMD=-0.58, 95%CI(-1.02, -0.13), P=0.01;I2 =89%〗, the infiltrating anesthesia group[SMD=-1.11, 95%CI( -1.94, -0. 28), P<0.009;I2 =88%] and the minor group[SMD=-1.20, 95%CI( -1.72, -0.68), P<0.00001;I2 =81%] by subgroup were statistical significance in secondary outcome of between 12 to 24 hours after the surgery;the overall group[ SMD=-1.09, 95%CI(-1.78, -0.39), P=0.002;I2 =67%], the topical anaesthetic group[SMD=-0.71, 95%CI(-1. 12, -0.30), P=0.0007;I2 =0%], the infiltrating anesthesia group[SMD=-1.70, 95%CI( -2.43, -0.98), P<0. 00001;I2 =NA], the minor group[SMD=-1.13, 95%CI( -2.18, -0.08), P=0.04;I2 =83%] and the adult group [SMD=-1.05, 95%CI(-2.00, -0.10), P=0.03;I2 =NA] by subgroup were statistical significance in secondary out-come of between 1 to 5 days after the surgery.Publication bias was not detected by funnel plot in our main outcome.The re-sults of sensitivity analysis were more robust.Conclusion The effects of topical anaesthesia was significant but short duration, while the infiltrating anesthesia had certain advantage of remote curative effect, simultaneously, the effect of local anesthesia drugs is remarkable for minor.%目的：系统评价局部麻醉对扁桃体摘除术后不同时间段疼痛的影响。方法通过计算机检索PubMed、Embase、The Cochrane Library（2014年11期）、CNKI、Wanfangdata及VIP数据库，收集建库至2014年11月所有以中英文形式公开发表关于局部麻醉对扁桃体摘除术后不同时间段疼痛缓解疗效的研究。依据纳入排除标准，筛选文献提取数据后，采用RevMen 5．2软件进行Meta分析。结果共纳入16个研究。 Meta分析结果显示：术后4～6 h疼痛评分，试验组低于对照组[SMD＝－0．63，95％CI（－1．00，－0．25），P＝0．0009，I2＝86％]；分亚组后表面麻醉组和未成年组均低于对照组[SMD＝－0．61，95％CI（－1．02，－0.20），P＝0．004，I2＝83％；SMD＝－1．19，95％CI（－1．54，－0．84），P＜0．01，I2＝67％]。术后3 h内疼痛评分，试验组低于对照组[SMD＝－0．72，95％CI（－1．27，－0．16），P＝0．01，I2＝88％]；亚组后未成年组低于对照组[SMD＝－1．01，95％CI（－1．49，－0．54），P＜0．01；I2＝80％]。术后12～24 h疼痛评分，试验组低于对照组[SMD＝－0．58，95％CI（－1．02，－0．13），P＝0．01，I2＝89％]；亚组后局部浸润麻醉组低于对照组[SMD＝－1.11，95％CI（－1．94，－0．28），P＜0．01，I2＝88％]，未成年组低于对照组[SMD＝－1．20，95％CI（－1．72，－0．68），P＜0．01，I2＝81％]。术后1～5 d疼痛评分，试验组低于对照组[SMD＝－1．09，95％CI（－1．78，－0．39），P＝0．002，I2＝67％]；亚组后表面麻醉组、局部浸润麻醉组、未成年组及成年组均低于对照组[SMD＝－0．71，95％CI（－1．12，－0．30），P＝0．0007，I2＝0％；SMD＝－1．70，95％CI（－2．43，－0．98），P＜0．01，I2＝NA；SMD＝－1．13，95％CI（－2.18，－0．08），P＝0．04，I2＝83％；SMD＝－1．05，95％CI（－2．00，－0．10），P＝0．03，I2＝NA]。术后4～6 h疼痛评分漏斗图未显示发表偏倚。敏感性分析提示结果稳定。结论表面麻醉术后镇痛显著但持续时间短，而局部浸润麻醉镇痛具有一定远期疗效优势；同时，局麻药物对未成年患者疗效显著。
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