大黄附子汤对脾肾阳虚型慢传输型便秘大鼠排便功能的影响研究

摘要

Objective It is to explore the mechanisms and best compatibility of Daihuang Fuzi Decoction on slow transit constipation ( Yang deficiency type ) .Methods The rat model of slow transit constipation ( Yang deficiency type ) were estab-lished by using compound diphenoxylate and white vinegar , then they were treated with Daihuang Fuzi Decoction of different compatibility for 7 day by gavage , the changes of defecation function , ink propulsion rates and interstitial cells of cajal of the rats were observed .Results There was a good increase of the amount of feces and the ink propulsion rates compared with the models when the dose of Fuzi was equal or greater than the dose of Daihuang .There was a good increase of interstitial cells of cajal when the dose of Fuzi was greater than the dose of Daihuang .Conclusion In this experiment,Daihuang Fuzi Decoction had exactly therapeutic effect on rats of slow transit constipation ( Yang deficiency type ) , it had best effect when the dose of Fuzi was greater than the dose of Daihuang .Its effect mechanism was probably related to the changes of Yang deficiency symp -tom,the ink propulsion rates and interstitial cells of cajal .%目的：研究大黄附子汤治疗脾肾阳虚型慢传输型便秘的作用机制及最佳配比。方法建立脾肾阳虚型慢传输型便秘大鼠模型，连续7d灌胃不同配比的大黄附子汤，观察不同配比大黄附子汤对模型大鼠排便功能、小肠推进率、结肠ICC细胞数目的影响。结果大黄附子汤在附子剂量≥大黄剂量时，可以显著增加模型大鼠的排便量、小肠推进率，且附子剂量＞大黄剂量时改善更明显，还可以显著增加结肠ICC细胞的数目。结论大黄附子汤对脾肾阳虚型慢传输型便秘作用确切，且附子剂量＞大黄剂量时效果最佳，机制可能与大黄附子汤纠正脾肾阳虚证候，改善小肠推进率，增加结肠ICC的数量有关。