In order to study the translocation of certain indigenous bacteria from the gastrointestinal tract in a mouse feeded probiotic culture. The spore of B. coagulans, pathogenic bacteria including Salmonella mutant, Escberichia coli K88 and the mixtures of the spores and pathogenic bacteria were orally administered to mice. And then, the growth performance of mice were statistics, certain indigenous bacteria from the gastrointestinal tract in the liver, the spleen and the blood from the mouse model were examined after 6day, The results showed that the mean weight in different experiments teams has variation, among them, the increased weight values of the team orally administed the spores was obviously comparation with that of other teams, which revealed that B. coagulans spore were germinative, propagative and promotion animal growth; In addition, no gastrointestinal tract bacteria were examed in the liver, the spleen and the blood of the mouse in the control and oral administion spores, while there were translocated gastrointestinal tract bacteria in the teams of oral administion pathogenic bacteria and mixtures with spore and pathogenic bacteria. It should emphasis that there were lower translocation gastrointestinal tract bacteria in the mixture teams compare with that in the.teams of oral administion pathogenic bacteria. Therefore, our study revealed that B. eoagulans spore has probiotic characteristics that anti-gastrointestinal tract bacteria translocation and pevetion and control intestinal tract disease occurres.%本试验研究凝结芽孢杆菌对肠道细菌易位的影响。采用形成芽孢的凝结芽孢菌、肠道致病菌（沙门氏菌，大肠杆菌K88）及其的混合物对小鼠灌胃饲养，连续饲喂6d后，统计小鼠的生长性能，检测肝脏、脾和血液中的肠道细菌数目。结果表明，各个灌服组小鼠平均增重变化较大，其中芽孢灌服组的增重最明显，揭示该菌芽孢在肠道内可发芽、增值、促进动物生长；此外，在对照组和芽孢灌服组的血液、肝脏和脾脏中没有检测到肠道细菌，而致病菌组及其混合组均出现肠道细菌易位的现象，只是在混合组检测到易位细菌的数量少很多。本研究说明凝结芽孢菌具有拮抗肠道菌群易位、防治肠道疾病发生的作用。
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