Objective To explore the effect of postoperative transarterial chemoemblization (TACE) on recurrence of high-risk patients after resection of hepatocellular carcinoma. Methods Eighty-six high-risk patients after surgical resection of hepatocellular carcinoma were divided into TACE group and control group.Forty-seven patients in TACE group received TACE 1 - 2 months after resection. the other 39 patients in control group were treated without TACE. The high-risk factors were defined as single tumor ＞ 5 cm or tumor nodules≥2 or with the presence of microscopic tumor thrombus. Results Recurrent rate of TACE goup was higher than that of control group at 12 th month post-resection(32.43％ vs 17.95％, P＜ 0.05), but there was no signfficant difference on recurrent rates between two groups at 24th month post-resechon (48.9％ vs 48.72％,P = 0.8224).The median survival time was 26 months in TACE group which was comparable to 22 months in control group (P = 0.0498). Conclusion Postoperative TACE has no effect on recurrence, but may be of benefit to detect residual tumor and prolong the median survival time.%目的 探讨原发性肝癌切除术后肝动脉化疗栓塞(TACE)的疗效.方法 将86例肝癌术后的高危复发患者分为干预组(TACE治疗组)和对照组(未行TACE治疗组).术后高危复发的标准为:①单发病灶>5 cm;②病灶数≥2处;③术后病理检查有镜下癌栓.符合其中任意一条为术后高危复发患者.干预组术后1～2月行TACE治疗.结果 术后12个月内干预组复发率为32.43%,对照组为17.95%,干预组高于对照组;24个月总体复发率干预组为48.94%,对照组为48.72%,两组相当,差异无统计学意义(P=0.8224).干预组中位生存期26个月;对照组中位生存期22个月;两组比较差异有统计学意义(P=0.0498).结论 原发性肝癌外科切除术后,对高危复发患者行TACE治疗能使肝内残留灶早发现、早治疗.是延长生存期的有效治疗方法之一,但并不能降低术后复发率.
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