沙利度胺治疗小肠血管发育不良所致消化道出血的疗效观察

摘要

Objective To observe the therapeutic effect of thalidomide on small intestinal bleeding caused by angiodysplasia. Methods Twenty patients with recurrent small intestinal bleeding caused by an-giodysplasia were treated with thalidomide 100 mg daily for 4 months. Follow-up time was 12 months. The change of clinical setting between pre-therapy and post-therapy was compared. Results The clinical setting of patients in post therapy was significantly better than that in pre-therapy. The overall symptom score, the medi-an bleeding frequency and median transfusion volume in patients after therapy was significantly lower than those before the therapy (14.56 ± 3.30) vs (5.23 ± 3.25), (11.12 ± 5.73) vs (1.00 ± 1.13), (1338.22 ± 1451.32) mL vs (100.00 ± 230.01)mL, respectively, (all P<0.01), while median hemoglobin was obviously higher than that before the therapy(5.68 ± 1.60)g/mL vs (9.41 ± 2.17)g/mL (P<0.01). Conclusions Thalidomide is effec-tive in treating small intestinal bleeding caused by angiodysplasia.%目的：观察沙利度胺治疗小肠血管发育不良所致消化道出血的临床疗效。方法收集2009年1月～2011年10月小肠血管发育不良所致消化道出血患者20例，给予沙利度胺片100 mg/d口服，疗程4个月，观察治疗前、后患者临床疗效。结果患者临床疗效总评分由治疗前的（14.56±3.30）分降至治疗后的（5.23±3.25）分，差异有统计学意义（P<0.01）。随访期间，20例患者平均出血次数为（1.00±1.13）次，输血量为（100.00±230.01）mL，均比治疗前显著减少[（11.12±5.73）次和（1338.22±1451.32）mL，P值均<0.01]；治疗后血红蛋白含量为（9.41±2.17）g/mL，比治疗前的（5.68±1.60]g/mL）显著上升（P<0.01]。结论沙利度胺对小肠血管发育不良所致的消化道出血疗效显著，可望成为一种治疗小肠血管发育不良的有效药物。