食管癌患者NK细胞和T淋巴细胞免疫功能的检测及临床意义

摘要

目的：分析食管癌患者NK细胞和T淋巴细胞免疫功能的检测及临床意义。方法以87例食管癌患者为观察组，以80例健康者为对照组。分别对两组对象的外周血NK细胞（CD56）和T淋巴细胞（CD3、CD4、CD8）的水平进行检测。结果观察组患者外周血CD56、CD8水平均高于对照组（P＜0.05）；CD3、CD4水平均低于对照组（P＜0.05）。观察组患者不同肿瘤分期中，CD56、CD8水平呈递增趋势，即Ⅰ期＜Ⅱ期＜Ⅲ期（P＜0.05）；在CD3、CD4水平呈递减趋势，即Ⅰ期＞Ⅱ期＞Ⅲ期（P＜0.05）；有淋巴结转移组和无淋巴结转移组患者的NK细胞和T淋巴细胞指标值比较，差异均无统计学意义（P＞0.05）。结论食管癌患者存在细胞免疫功能下降，且下降趋势与肿瘤病情进程密切相关。%Objective To detect and analyze clinical significance of NK cells and T lymphocytes im-mune function in the patients with esophageal cancer. Methods The study included 87 patients with esophageal cancer (observation group) and 80 healthy persons (control group). The level of the NK cells (CD56) and the T lymphocytes (CD3, CD4 and CD8) of the peripheral blood in two groups were detected. Re-sults The level of CD56 and CD8 in observation group was higher than control group (P<0.05). However, the level of CD3 and CD4 was lower in observation group (P<0.05). According to different tumor staging, CD56 and CD8 showed increasing trend,Ⅰ<Ⅱ<Ⅲ(P<0.05), while CD3 and CD4 showed decreasing trend, Ⅰ>Ⅱ>Ⅲ(P<0.05). There was no statistically significant difference on the level of NK cells and T lymphocytes whether the patients with lymphatic metastasis or not (P>0.05). Conclusion Patients with esophageal cancer had a decrease of immunologic function, which was closely related to tumor progression. The detection of NK cells and T lymphocytes was meaningful for the condition judgment and treatment plan in esophageal cancer.