除草剂Tembotrione的合成研究

摘要

Tembotrione is an important product in HPPD herbicides. The synthetic methods of tembotrione used 3-chloro-2-methylaniline as the starting material. The target product was prepared via diazotization, Friedel-Crafts acylation, oxidization, haloform reaction, esterification, bromination, condensation, hydrolysis, chloridization, rearrangement reaction, etc. The total yield was more than 60%, the purity of tembotrione was over 95%.%Tembotrione为HPPD抑制剂类除草剂，具有三酮结构。以3-氯-2-甲基苯胺为起始原料，经由重氮化、傅克酰基化、氧化、卤仿、酯化、溴代、缩合、水解、酰氯化以及缩合、重排反应合成目标化合物tembotrione。该工艺总收率达到60%，目标产物质量分数在95%以上。工艺条件温和，原料易得，适合工业化大生产。