Research progress of Hippo kinase cascade and cardiovascular disease

摘要

The occurrence of cardiovascular events is one of the important causes of death and disability in the nation.The ischemia and hypoxia of myocardial cells caused by coronary atherosclerosis,intravascular stenosis or myocardial infarction leads to cell damage,necrosis and apoptosis,leading to Myocardial fibrosis affects cardiac function and the quality of life of patients.Reducing myocardial cell apoptosis,inhibiting myocardial fibrosis and promoting myocardial cell regeneration are of great significance for maintaining the normal shape and function of the heart.With the progress of research,scientists have discovered that the Hippo pathway plays an important role in the repair and regeneration of myocardial cells.This article reviews the regulatory effects and mechanisms of the various factors in the Hioop signaling pathway in the repair and regeneration of cardiomyocytes.