Objective To investigate expression of osteopontin (OPN) and adhesion molecule CD44v6 in colon adenocarcinoma and their clinical signiifcance. Methods 80 cases of colon cancer tissue were detected by immunohistochemical methods (with lymph node metastasis in 32 cases, 48 cases without lymph node metastasis), 30 cases of colorectal adenoma, 20 cases from colon tumor (polyp, adenoma, cancer, etc.) 5 cm above normal tissue osteopontin and CD44v6 expression levels were examined to analyze the correlation of osteopontin and CD44v6 expression in colon adenocarcinoma. Results Adenocarcinoma of the colon and surrounding lymph nodes, osteopontin and CD44v6 expression were signiifcantly higher than that of normal colon tissue and colonic adenoma expression levels (P<0.05), colon adenocarcinoma with metastasis in osteopontin CD44v6 protein expression levels were significantly higher than that of non-metastatic colon adenocarcinoma (P<0.05). Colon adenocarcinoma osteopontin expression and expression of CD44v6 were in a state of consistency (P<0.05). Conclusion OPN-CD44v6 with colon adenocarcinoma, developing consistent, osteopontin and CD44v6 joint detection for colon cancer development and prognosis explicitly provide a basis for clinical diagnosis and treatment , which has a certain signiifcance in clinical practices.%目的：研究结肠腺癌组织中骨桥蛋白和CD44v6的表达及其意义。方法用免疫组化法检测80例结肠腺癌组织（有淋巴结转移32例，无淋巴结转移48例）、30例结肠腺瘤组织、20例距结肠肿物（息肉、腺瘤、肿瘤等）5 cm以上的正常组织中骨桥蛋白和CD44v6的表达水平，并分析骨桥蛋白与CD44v6在结肠腺癌中表达的相关性。结果在结肠腺癌组织及其周围淋巴结中，骨桥蛋白和CD44v6的表达水平显著高于正常结肠组织和结肠腺瘤组织的表达水平（P<0.05），在有转移的结肠腺癌中骨桥蛋白与CD44v6的表达水平显著高于无转移的结肠腺癌组织（P<0.05）。结肠腺癌组织中骨桥蛋白的表达与CD44v6的表达具有一致性（P<0.05）。结论骨桥蛋白和CD44v6与结肠腺癌的发生、发展相一致，骨桥蛋白与CD44v6联合检测对于明确结肠腺癌发展及预后提供一定依据，对临床诊治具有一定指导意义。
展开▼
