It is found that the final effect of angioplasty is significantly limited by the high rate of rest-enosis, which is based on the abnormal proliferation and migration of vascular smooth muscle cells. PTEN is a new tumor suppressor gene discovered in recent years, which is also the first tumor suppressor gene with phos-phatase activity found so far,having an important impact on cell growth,proliferation and differentiation, ap-optosis,adhesion,migration and blood vessel growth, and many other biological behaviors. Along with the deepening of the study, researchers found it also played an important role in the non-neoplastic diseases, such as restenosis,cardiac hypertrophy,hypertension,and atherosclerosis,etc. .%再狭窄严重制约了经皮冠状动脉介入治疗的远期疗效.其病理基础是新生内膜的形成;而血管平滑肌细胞增殖和迁移则是其主要成因.PTEN是至今发现的第一个具有磷酸酶活性的抑癌基因.对细胞的生长、增殖、分化、凋亡、黏附、迁移和血管生长等许多生物学行为有重要影响.近年来,对PTEN的研究逐渐从肿瘤领域延伸到一些非肿瘤领域中,随着研究的深入,人们发现其在再狭窄、心肌肥大、高血压、动脉粥样硬化中也发挥重要的作用.
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