益生菌治疗肠易激综合征的相关机制

摘要

肠易激综合征(IBS)是最常见的功能性胃肠病之一,其病因及发病机制尚未完全明确.肠道菌群失调及小肠细菌过度生长与其发病关系密切,目前研究表明益生菌治疗可能为IBS的一种有效方法,现拟从益生菌调整肠道菌群失调、抑制小肠细菌过度生长、增强肠黏膜屏障、增强肠黏膜免疫、降低内脏高敏感性等几个方面对益生菌治疗肠易激综合征的相关机制及安全性等予以综述.%Irritable bowel syndrome( IBS )is one of the most common functional gastrointestinal disorders,of which the cause and the pathogenesis is not yet clear. Dysbacteria, small intestinal bacterial overgrowth and IBS are closely related, and recent studies have suggested that probiotics may be an effective treatment of IBS. Here is to focus on examining the related mechanism and safety of probiotics in the treatment of IBS( such as adjusting dysbacteria, inhibitting small intestinal bacterial overgrowth, strengthening intestinal mucosal barrier,improving intestinal mucosal immunity, reducing visceral hyperalgesia and so on ).