超重及肥胖型高血压患者血清瘦素与肿瘤坏死因子α水平的变化

摘要

Objective To explore the serum levels of leptin and TNF-αin essential hypertensive patients with overweight and obesity problem. Methods In 28 essential hypertension cases with normal weight and 31 essential hypertensive patients with overweight and obesity problem,regular indexes including blood pressure, body mass, height were measured, body weight index were calculated; and blood glucose, lipids, fasting insulin,serum, tumor necrosis factor-α, leptin, and blood glucose 2 h after intake of sugar were also examined. Results The systolic blood pressure,serum total cholesterol,leptin levels were higher in essential hypertension patients with overweight and obesity problem than those in essential hypertension patients with normal weight, while the high density lipoprotein cholesterol level was lower in essential hypertension patients with overweight and obesity problem( P ＜ 0.05 ). Related analysis showed that systolic blood pressure were positively correlated with age, body mass index and serum leptin concentrations in essential hypertension patients with overweight and obesity problem. Conclusion In essential hypertension patients with overweight and obesity problem,the systolic blood pressure, serum total cholesterol, leptin levels are higher while high density lipoprotein cholesterol is lower,the systolic blood pressure level is closely associated with age, body mass index and leptin.%目的探讨在超重及肥胖型高血压病患者中,肿瘤坏死因子α(TNF-α)、瘦素水平是否升高及其影响因素.方法 28例体质量正常和31例超重及肥胖型的高血压患者,常规测量血压、体质量、身高,计算体质量指数,检测血糖、血脂、空腹胰岛素、血清TNF-α、瘦素和服糖后2 h血糖.结果与体质量正常高血压患者相比,超重及肥胖型高血压患者的收缩压、血清总胆固醇、瘦素水平增高,而血清高密度脂蛋白胆固醇水平下降,两组之间差异有统计学意义(P＜0.05);相关分析提示超重及肥胖型高血压患者中收缩压与年龄、体质量指数、瘦素之间存在正相关.结论在超重及肥胖型高血压患者中,收缩压、血清总胆固醇和瘦素水平增高,高密度脂蛋白胆固醇水平下降,收缩压与年龄、体质量指数和瘦素水平密切相关.