白细胞介素18与特应性皮炎的研究进展

摘要

Interleukin-18( IL-18 )is a recently identified important pro-inflammatory cytokine,with a variety of biological activities. Atopic dermatitis( AD )is a chronic relapsing skin disease and IL-18 is involved in the pathogenesis of AD. IL-18 can play a role in the immunopathogenesis of AD, and thus is a candidate therapeutic target.%白细胞介素18(IL-18)具有多种生物学活性,在许多疾病和治疗中都具有重要的基础研究及临床应用前景.IL-18在特应性皮炎(AD)患者血清、皮肤角质层细胞、基因多态性表达等均存在异常,可通过影响AD患者皮损金黄色葡萄球菌感染、Th1/Th2细胞的失衡、皮肤屏障作用及角质形成细胞等方面,在AD发病机制中发挥作用.以IL-18为靶点或效应剂治疗AD是一种新的、有益的尝试.