碘过量与甲状腺功能的关系

摘要

Iodine is a necessary microelement,the physiological function of which is carried out by thyroid hormone. Absence or excessiveness of iodine could lead to thyroid diseases. Along with promotion of iodized salt, the incidence of thyroid diseases rised. Excessive iodine affects thyroid funcion by repressing the iOdine organification , activity of deiodinase , and expression of NIS ; and since neonatal TSH level is associated with idion deficiency or excessiveness,further discussion is needed to decide if the index can be used for evaluation of iodine nutrition level. The key of iodine disease prevention and treatment should be adjusting measures to local conditions.%碘是人体所必需的一种微量元素,并通过甲状腺激素来体现其生理功能,碘缺乏和碘过量都可以引起甲状腺疾病.随着加碘盐的实施,碘过量导致的甲状腺疾病发生增加.过量碘可抑制碘的有机化、脱碘酶活性及甲状腺钠碘转运体的表达,影响甲状腺功能;新生儿促甲状腺素水平与该地区碘营养不足或过量都有关联,因此,该指标作为评价人群碘营养状况的判断指标有待探讨.因地制宜,科学补碘是防治碘缺乏病的关键.