Neisseria gonorrhoeae has presented different degrees of resistance to the commonly used antibiotics due to the widely use of antibiotics. Here is to review the main mechanisms of drug resistance of Neisseria gonorrhoeae and the research advances of drug resistance genes , mainly including : alteration of PBPs intracellularaction target resulting in the resistence to antibiotics such as penicillin ; drug resistance to quinolone and the relation with gyrA, parC and norm gene mutation ; the multiple transferable resistance( mtr )efflux system reducing the permeability of multiple antibiotics; the protein encoded by teM-1 and tetM inhibitting toxicity of tetracyclines; drug resistance to azithromycin and spectinomycin and the relation with the alteration of the target positions.%随着抗生素的广泛使用,淋病奈瑟菌对常用的抗生素产生了不同程度的耐药.现综述近年淋病奈瑟菌的耐药性及耐药基因的研究进展,包括:改变PBPs的胞内作用靶位,导致对青霉素类抗生素的耐药,gyrA基因、parC基因和norm基因的突变,导致对氟喹诺酮类抗生素的耐药,药物外排机制引起多重抗生素的通透性降低,teM-1基因和tetM基因编码的胞质蛋白抑制了四环素类药物对细菌的毒性作用,阿奇霉素和大观霉素耐药与作用靶位的改变等.
展开▼
